Llangefni didn't play last weekend, with their last fixture being two weeks ago when they lost 7-0 to Flint Town United.
Llandudno's last game was also against Flint, which ended in a 1-1 draw despite Aaron Pomeyie opening the scoring on the 7th minute.
That draw made Llandudno unbeaten in three games and sees them in eighth position in the JD Cymru North.
Manager Matthew Jones expects a difficult game against Llangefni tomorrow night.
"I expect a very tough game Friday from a side that is well drilled and very disciplined. I've seen Llangefni twice this season and what's clear is that Chris has set the team up with the plan and their players execute that plan." Said Matty.
"The key for us will be to successfully implement our own game plan and display the qualities that we have within the group."
On Llandudno's good recent form, Matty has praised the squad depth that he has in his disposal this season.
"What's pleasing is that we have good strength in depth and the players that haven't been playing are knocking on the door with their performances in training and off the bench."
"These are difficult decisions but it's great to be in this position to make those decisions." Said Matty.
Jacob Farleigh returned from injury and came off the bench last time out against Flint, and could feature again tomorrow night.
"We have a couple of doubts, Lewis Sirrell is still unavailablel and Bailey Jackson will miss out through injury. We will also have a late check on Jacob Farleigh."
Llandudno don't play next weekend so will be looking to take a good performance and all three points into the weekend break, ahead of playing league leaders Prestatyn Town at Maesdu Park the following midweek.